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Necrostatin 2 racemate
CAS No. 852391-15-2
Necrostatin 2 racemate( Necrostatin-2 racemate )
Catalog No. M20772 CAS No. 852391-15-2
Necrostatin 2 racemate is an potent and specific inhibitor of?RIPK1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 98 | In Stock |
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| 10MG | 155 | In Stock |
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| 25MG | 290 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 705 | In Stock |
|
| 500MG | 1431 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNecrostatin 2 racemate
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NoteResearch use only, not for human use.
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Brief DescriptionNecrostatin 2 racemate is an potent and specific inhibitor of?RIPK1.
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DescriptionNecrostatin 2 racemate is an potent and specific inhibitor of?RIPK1.
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In VitroNecrostatin 2 racemate (Nec-1S) (1-100 μM; 1 h) potently inhibits RIPK1 autophosphorylation in a dose-dependent manner.
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In VivoNecrostatin 2 racemate (Nec-1S) (6 mg/kg; i.v.; once) protects against TNF-induced systemic inflammatory response syndrome (SIRS) without sensitization effect. Animal Model:Female C57BL/6J WT mice, SIRS model Dosage:0.6 mg/kg or 6 mg/kg Administration:Intravenous injection, once Result:Showed protective effect at 6 mg/kg.
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SynonymsNecrostatin-2 racemate
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIPK1
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Research Area——
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Indication——
Chemical Information
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CAS Number852391-15-2
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Formula Weight277.71
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Molecular FormulaC13H12ClN3O2
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Purity>98% (HPLC)
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SolubilityDMSO:50 mg/mL (180.04 mM)
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SMILESCN1C(=O)NC(Cc2c[nH]c3c(Cl)cccc23)C1=O
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Chemical Name5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-24-imidazolidinedione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Takahashi N Duprez L Grootjans S et al. Necrostatin-1 analogues: critical issues on the specificity activity and in vivo use in experimental disease models[J]. Cell Death and Disease 2012 3(11):e437.
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